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These quinolones have proved very effective against the
pathogens causing serious respiratory tract (RTI) and urinary
tract infections (UTI) and offer good concentration in these
areas. However, there are some restrictions on their use
that lie at both ends of the age scale.
- They
tend not to be indicated for children and young adults
because of their chondrotoxicity side effects.
- With
elderly people who are often receiving a cocktail of drugs
for unrelated conditions, the drug interaction potential
may be problematic.
- Another
side effect, seen in some quinolones, is phototoxicity
and this has been a problem with those most potent in
terms of antibiotic activity.
- An
extremely rare but serious side effect noted with one
of the most potent fluoroquinolones has been liver toxicity.
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